HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(3-chloropropyl)-2,3-dihydro-1H-isoindol-5-yl]propan-1-one → 1-(2-{3-[(4-Methyl-5-pyridin-3-yl-4H-1,2,4-triazol-3-yl)thio]propyl}-2,3-dihydro-1H-isoindol-5-yl)propan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(3-chloropropyl)-2,3-dihydro-1H-isoindol-5-yl]propan-1-one | HCID 69153209 | — |
| Reactant | HCID 178481688 | HCID 178481688 | — |
| Product | 1-(2-{3-[(4-Methyl-5-pyridin-3-yl-4H-1,2,4-triazol-3-yl)thio]propyl}-2,3-dihydro-1H-isoindol-5-yl)propan-1-one | HCID 69152729 | — |
Reaction Steps
The title compound was prepared in analogy to method 1.5 from 4-methyl-5-pyridin-3-yl-4H-1,2,4-triazole-3-thiol (1.43 mmol, 0.33 g) and 1-[2-(3-chloropropyl)-2,3-dihydro-1H-isoindol-5-yl]propan-1-one (1.43 mmol, 0.36 g; preparation in analogy to 1.4 from isoindoline as disclosed in WO 0125200). Yield: 0.04 g.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07465744B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-6b92ebe2e79142aba7460e9c4d48760b |
| Source note | uspto-grants-2008_12 |