Hydrazine → HCID 11724147, compound

HRID 2375391Notes

Reaction equation

HRID 2375391 reaction equation
[C:1]([C:4]1[C:5]([C:21](=O)[CH3:22])=[C:6]([CH3:20])[N:7]([C:10]2[CH:15]=[CH:14][C:13]([O:16][CH2:17][CH3:18])=[C:12]([Cl:19])[CH:11]=2)[C:8]=1[CH3:9])(=O)[CH3:2].[NH2:24][NH2:25]>>[Cl:19][C:12]1[CH:11]=[C:10]([N:7]2[C:8]([CH3:9])=[C:4]3[C:5]([C:21]([CH3:22])=[N:24][N:25]=[C:1]3[CH3:2])=[C:6]2[CH3:20])[CH:15]=[CH:14][C:13]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 9321HydrazineHCID 69275411HCID 69275411, compound

Product 1

HCID 11724147HCID 11724147, compound

Procedure

Utilizing the general procedure outlined in Example 48, 1-[4-acetyl-1-(3-chloro-4-ethoxy-phenyl)-2,5-dimethyl-1H-pyrrol-3-yl]-ethanone and hydrazine reacted to give 6-(3-Chloro-4-ethoxy-phenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]pyridazine as yellow solid: 1H NMR (CD3OD, 500 MHz) δ 7.47 (s, 1H), 7.32 (d, 1H), 7.25 (d, 1H), 4.27 (q, 2H), 2.79 (s, 6H), 2.48 (s, 6H), 1.53 (t, 3H); MS (ESI) 330 (M+H)+.

Workup

  1. customreacted

Sources & evidence

ORD record
ord-c90b8d79a6ae4edb86657b76e309395e
Source dataset
uspto-grants-2008_12
Patent number
US07465730B2

Reaction notes

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