Hydrazine → HCID 10381545, compound

HRID 2375417Notes

Reaction equation

HRID 2375417 reaction equation
[C:1]([CH:4]([C:12](=O)[CH3:13])[CH:5]([C:9](=O)[CH3:10])[C:6](=O)[CH3:7])(=O)[CH3:2].[CH2:15]([O:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21]([NH2:25])=[C:20]([CH3:26])[CH:19]=1)[CH3:16].[NH2:27][NH2:28]>>[CH2:15]([O:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21]([N:25]2[C:1]([CH3:2])=[C:4]3[C:5]([C:9]([CH3:10])=[N:27][N:28]=[C:12]3[CH3:13])=[C:6]2[CH3:7])=[C:20]([CH3:26])[CH:19]=1)[CH3:16]

Participants

4

Reactant 3

HCID 9321HydrazineHCID 787303,4-Diacetyl-2,5-hexanedioneHCID 30415212,6-Xylidine, 4-ethoxy-

Product 1

HCID 10381545HCID 10381545, compound

Procedure

Utilizing the general procedure outlined in Example 48, 1,1,2,2-tetraacetylethane (308 mg, 1.56 mol), 4-ethoxy-2,6-dimethyl-phenylamine (250 mg, 1.0 mmol) and hydrazine (100 μL) reacted to give 6-(4-ethoxy-2,6-dimethyl-phenyl)-1,4,5,7-tetramethyl-6H-pyrrolo[3,4-d]-pyridazine as yellow solid: 1H NM (CDCl3, 500 MHz) δ 6.81 (s, 1H), 6.75 (s, 1H), 4.04 (q, 2H), 2.82 (s, 6H), 2.44 (s, 6H), 2.47 (s, 3H), 2.35 (s, 6H), 1.79 (s, 3H), 1.88 (t, 3H), ; MS (ESI) 324 (M+H)+.

Workup

  1. customreacted

Sources & evidence

ORD record
ord-160d09e213064debb9b726f2093a4545
Source dataset
uspto-grants-2008_12
Patent number
US07465730B2

Reaction notes

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