Hydrazine → HCID 10404056, compound

HRID 2375421Notes

Reaction equation

HRID 2375421 reaction equation
[C:1]([CH:4]([C:12](=O)[CH3:13])[CH:5]([C:9](=O)[CH3:10])[C:6](=O)[CH3:7])(=O)[CH3:2].[NH2:15][C:16]1[CH:17]=[CH:18][C:19]([O:24][CH2:25][CH3:26])=[C:20]([CH2:22][OH:23])[CH:21]=1.[NH2:27][NH2:28]>>[CH2:25]([O:24][C:19]1[CH:18]=[CH:17][C:16]([N:15]2[C:1]([CH3:2])=[C:4]3[C:5]([C:9]([CH3:10])=[N:27][N:28]=[C:12]3[CH3:13])=[C:6]2[CH3:7])=[CH:21][C:20]=1[CH2:22][OH:23])[CH3:26]

Participants

4

Reactant 3

HCID 9321HydrazineHCID 787303,4-Diacetyl-2,5-hexanedioneHCID 43260219(5-Amino-2-ethoxyphenyl)methanol

Product 1

HCID 10404056HCID 10404056, compound

Procedure

Utilizing the general procedure outlined in Example 48, 1,1,2,2-tetraacetylethane (308 mg, 1.56 mol), (5-amino-2-ethoxy-phenyl)-methanol (250 mg, 1.0 mmol) and hydrazine (100 μL) reacted to give [2-ethoxy-5-(1,4,5,7-tetramethyl-pyrrolo[3,4-d]pyridazin-6-yl)-phenyl]-methanol as yellow solid: 1H NMR (CDCl3, 500 MHz) δ 7.24 (s, 1H), 7.08-7.01 (m, 2H), 4.81 (s, 2H), 4.18 (q, 2H), 2.77 (s, 6H), 2.43 (s, 6H), 1.51 (t, 3H); MS (ESI) 326 (M+H)+.

Workup

  1. customreacted

Sources & evidence

ORD record
ord-77fbf16f40d243038dda686c1eea27bb
Source dataset
uspto-grants-2008_12
Patent number
US07465730B2

Reaction notes

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