Water → HCID 10821988, compound

Participants

Reaction Conditions

Reaction Steps

The compound (3R)-1-benzyl-3-[(methylsulfonyl) oxy]pyrrolidine (1.3 g, 5.8 mM) was dissolved in dimethylformamide (25.0 ml) and sodium azide (1.5 g, 23.3 mM) was added to it. The reaction mixture was maintained at 90-100° C. for about 12 hours followed by cooling at room temperature. The reaction mixture was poured into cold water (150.0 ml) with constant stirring. The organic compound was extracted with ethyl acetate and washed with water and brine solution, dried over anhydrous sodium sulphate and concentrated to give the title compound. Yield=78% (0.9 g, 4.5 m. This material was used as such in the next step.

Provenance & Evidence