HCID 9999727, compound → HCID 69318700, compound

Participants

Reaction Steps

The compound 2-cyclopentyl-2-hydroxy-N-[(3S)-1-benzyl-pyrrolidin-3-yl]-2-phenyl-acetamide (0.8 g, 2.12 mM) was dissolved in methanol (20.0 ml) and 10% palladium on carbon (0.2 g) is added. After hydrogenating at room temperature for 10 hours at 65-70 psi, the second lot of 10% palladium on carbon (0.2 g) was added and hydrogenation was continued for 10 more hours at 65-70 psi at room temperature. The reaction mixture was diluted with methanol and filtered through a bed of hyflo. The filtrate was concentrated under vacuum and used as such in the next step.

Provenance & Evidence