Trifluoroacetic acid → HCID 86697210, compound

Participants

Reaction Steps

To a solution of N,N-di-tert.-butoxycarbonyl-2-(4-bromo-3,5-dimethylphenyl)ethanamine (1.19 g) in dichloromethane (25 mL) is added trifluoroacetic acid (320 μL). The mixture is stirred for 12 hours at room temperature. Then the mixture is partitioned between saturated aqueous NaHCO3 solution and dichloromethane. The organic phase is dried (MgSO4), the solvent is evaporated and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 99:1→70:30) to give the title compound. Yield: 550 mg; LC (method 8): tR=0.68 min; Mass spectrum (ESI+): m/z=328 [M+H]+.

Provenance & Evidence