HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[4-(dimethylamino)-6-(4-toluidino)-2-pyrimidinyl]-2-phenylacetamide → N4,N4-Dimethyl-N6-(4-methylphenyl)-N2-(2-phenylethyl)-2,4,6-pyrimidinetriamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[4-(dimethylamino)-6-(4-toluidino)-2-pyrimidinyl]-2-phenylacetamide | HCID 21101364 | — |
| Reactant | Aluminium lithium hydride | HCID 21226445 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | N4,N4-Dimethyl-N6-(4-methylphenyl)-N2-(2-phenylethyl)-2,4,6-pyrimidinetriamine | HCID 58863874 | — |
Reaction Steps
A mixture of N-[4-(dimethylamino)-6-(4-toluidino)-2-pyrimidinyl]-2-phenylacetamide (60 mg, 0.166 mmol), and LAH (1 mL, 1M in THF) in THF (10 mL) was refluxed for 3 h.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07465750B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-f5bb13add13e4110ae9568cf0754d317 |
| Source note | uspto-grants-2008_12 |