Acetyl chloride → HCID 86697212, compound

Participants

Reaction Conditions

Reaction Steps

To a cooled (0° C.) solution of 2-(4-bromo-3,5-dimethylphenyl)ethanamine (100 mg) and triethylamine (68 μL) in dichloromethane (3 mL) is added acetyl chloride (31 μL). The mixture is stirred for 2 hours at 0° C. Then the mixture is partitioned between dichloromethane and water. The organic phase is separated and dried (MgSO4). The solvent is evaporated and the residue is purified by HPLC on reversed phase to give the title compound. Yield: 25 mg; LC (method 7): tR=0.98 min; Mass spectrum (ESI+): m/z=270 [M+H]+.

Provenance & Evidence