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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237549Generated: October 29, 2026

{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 86697213, compound

https://huagongshe.com/reaction/237549

Reaction equation

Participants

RoleNameHCIDCharge
Reactant{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697103—
Reactant{(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697106—
ReactantHCID 86697212HCID 86697212—
ProductHCID 86697213HCID 86697213—

Reaction Steps

The title compound is prepared from methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate and N-(4-bromo-3,5-dimethylphenethyl)acetamide following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 8): tR=0.53 min; Mass spectrum (ESI+): m/z=532 [M+H]+.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08642585B2
Source datasetuspto-grants-2014_02
ORD IDord-aafd8e691a494815866d3350f502fa60
Source noteuspto-grants-2014_02