HuagongsheHuagongshe Chemistry Print Report · For research reference only
7-ethyl-2,3-dihydro-1H-indole-2,3-dione → 7-Phenylisatin
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 7-ethyl-2,3-dihydro-1H-indole-2,3-dione | HCID 247365 | — |
| Reactant | 2-(4-chlorobenzyl)-8-ethyl-3-hydroxyquinoline-4-carboxylic Acid | HCID 11152028 | — |
| Reactant | 2-(4-Chloro-benzyl)-3-hydroxy-8-phenyl-quinoline-4-carboxylic Acid | HCID 11383708 | — |
| Reactant | 1-(Acetyloxy)-3-(4-chlorophenyl)-2-propanone | HCID 12222464 | — |
| Product | 7-Phenylisatin | HCID 10775447 | 25% |
Reaction Steps
This compound was synthesized by the procedure described above for Compound 2, reacting 7-ethyl-1H-indole-2,3-dione (1.00 g, 5.71 mmol) with intermediate 2 (1.62 g, 7.14 mmol). The crude acid was purified as described above for Compound 3 to give product as a bright yellow powder (Compound 7, 0.488 g, 25% yield): 1H NMR (400 MHz, DMSO-D6) δ 1.21 (t, J=7.5 Hz, 3H) 3.11 (q, J=7.3 Hz, 2H) 4.32 (s, 2H) 7.34 (s, 4H) 7.40 (d, J=7.1 Hz, 1H) 7.46 (t, 1H) 8.32 (d, J=8.1 Hz, 1H); HRMS (ESI+) calcd for C19H17ClNO3 (MH+) 342.0892, found 342.0890.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07465799B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-beb1f9e774724089b515918872dd7fb7 |
| Source note | uspto-grants-2008_12 |