HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloral Hydrate → Acetamide, 2-(hydroxyimino)-N-phenyl-
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloral Hydrate | HCID 2707 | — |
| Reactant | Isatin | HCID 7054 | — |
| Reactant | 1-Naphthylamine | HCID 8640 | — |
| Reactant | Sodium Sulfate | HCID 24436 | — |
| Reactant | Hydroxyamine hydrochloride | HCID 443297 | — |
| Product | Acetamide, 2-(hydroxyimino)-N-phenyl- | HCID 6861488 | 34% |
Reaction Steps
The procedure described above for the synthesis of intermediate 3 was followed, reacting 1-aminonaphthalene (10.0 g, 69.8 mmol) with chloral hydrate (13.9 g, 83.8 mmol) and hydroxylamine hydrochloride (17.5 g, 0.251 mol) in the presence of sodium sulfate (99 g, 0.70 mol). Isonitrosoacetanilide was obtained as a brownish-black solid (7.09 g, 47% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07465798B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-7b66f0ee80814432a802f8e66fffa71a |
| Source note | uspto-grants-2008_12 |