{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 86697228, compound

HRID 237566Notes

Reaction equation

HRID 237566 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]2[C:10]=1[C:9](=[O:11])[CH2:8][CH2:7]2.BrC1C=CC(F)=C2C=1CC[C@H]2OC1C=CC2[C@H](CC(OC)=O)COC=2C=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:12]2[CH2:17][CH2:16][O:15][CH2:14][CH2:13]2)=[C:6]2[C:10]=1[C@@H:9]([OH:11])[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 86697103{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 86697226HCID 86697226, compound

Product 1

HCID 86697228HCID 86697228, compound

Procedure

The title compound is prepared from 7-fluoro-4-(tetrahydro-2H-pyran-4-yl)-2,3-dihydro-1H-inden-1-one following a procedure analogous to that described in Step 2 of Intermediate 1. Mass spectrum (ESI+): m/z=363 [M+Na]+.

Sources & evidence

ORD record
ord-17d91768593b4a0a8abe2ed82a68b371
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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