N-bromobutanimide → (2-Bromo-5-((3-methyloxetan-3-yl)methoxy)-1,3-phenylene)dimethanol

Participants

Reaction Steps

NBS (212 mg) is added to ((5-((3-Methyloxetan-3-yl)methoxy)-1,3-phenylene)dimethanol (270 mg) in acetonitrile (5 mL) and the resulting mixture is stirred at room temperature for 3 h. The solvent is evaporated in vacuo and the residue is chromatographed on silica gel (cyclohexane/ethyl acetate 50:50→0:100) to give the title compound. LC (method 7): tR=0.76 min; Mass spectrum (ESI−): m/z=315 [M−H]−.

Provenance & Evidence