2-Bromo-5-iodo-1,3-dimethylbenzene → 5-(4-Bromo-3,5-dimethylphenyl)-1-methylpyridin-2(1H)-one

HRID 237577Notes

Reaction equation

HRID 237577 reaction equation
[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](I)=[CH:4][C:3]=1[CH3:10].[CH3:11][N:12]1[CH:17]=[C:16](B2OC(C)(C)C(C)(C)O2)[CH:15]=[CH:14][C:13]1=[O:27]>>[Br:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5]([C:16]2[CH:15]=[CH:14][C:13](=[O:27])[N:12]([CH3:11])[CH:17]=2)=[CH:4][C:3]=1[CH3:10]

Participants

3

Reactant 2

HCID 207480372-Bromo-5-iodo-1,3-dimethylbenzeneHCID 454801941-Methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one

Product 1

HCID 866972415-(4-Bromo-3,5-dimethylphenyl)-1-methylpyridin-2(1H)-one

Procedure

The title compound is prepared from 2-bromo-5-iodo-1,3-dimethylbenzene and 1-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2(1H)-one following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 11): tR=1.05 min; Mass spectrum (ESI+): m/z=292, 294 [M+H]+.

Sources & evidence

ORD record
ord-34a922a22eea4f12aefe2d867460d056
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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