2-Bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzene → HCID 11276427, compound

HRID 2375778Notes

Reaction equation

HRID 2375778 reaction equation
[C:1]([C:3]1[CH:4]=[C:5]([B:9]2[O:13][CH2:12][CH2:11]O2)[CH:6]=[CH:7][CH:8]=1)#[N:2].Br[C:15]1C=[CH:19][C:18]([F:21])=[CH:17][C:16]=1COCOC>>[F:21][C:18]1[CH:17]=[CH:16][C:15]2[B:9]([C:5]3[CH:4]=[C:3]([CH:8]=[CH:7][CH:6]=3)[C:1]#[N:2])[O:13][CH2:12][C:11]=2[CH:19]=1

Participants

3

Reactant 2

HCID 118455732-Bromo-5-fluoro-[1-(methoxymethoxy)methyl]benzeneHCID 667383483-(1,3,2-Dioxaborolan-2-yl)benzonitrile

Product 1

HCID 11276427HCID 11276427, compound

Procedure

This was prepared as per the procedure in Example 11, from 2-(3-cyanophenyl)-[1,3,2]-dioxaborolane and 1-bromo4-fluoro-2-((methoxymethoxy)methyl)benzene to afford white crystalline product.

Workup

  1. customto afford white crystalline product

Sources & evidence

ORD record
ord-5945796762c443dbb8fb96aea2ff19b3
Source dataset
uspto-grants-2008_12
Patent number
US07465836B2

Reaction notes

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