HCID 69287986, compound → HCID 69289214, compound

Participants

Reaction Steps

To a solution of 1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrrole-2-carboxylic acid ethyl ester (135 mg) in MeOH/THF/H2O (3:1:1, 5 mL) was added LiOH monohydrate (100 mg). The mixture was refluxed for 2 h after which it was cooled to RT and concentrated. The mixture was acidified by the addition of 1 N aqueous KHSO4 solution and extracted with ethyl acetate. The combined organic phases were dried (MgSO4) and concentrated in vacuo to provide crude 1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-1H-pyrrole-2-carboxylic acid (148 mg) which was directly used in the next step. MS (ESI−): m/e=307 [M−H]−, chloro pattern.

Provenance & Evidence