HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 237579Generated: October 26, 2026
1H-1,2,4-Triazole → 1-(4-Bromo-3,5-dimethylphenyl)-1H-1,2,4-triazole
https://huagongshe.com/reaction/237579
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1H-1,2,4-Triazole | HCID 9257 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Bromo-5-iodo-1,3-dimethylbenzene | HCID 20748037 | — |
| Catalyst | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 1-(4-Bromo-3,5-dimethylphenyl)-1H-1,2,4-triazole | HCID 86697243 | — |
Reaction Steps
A mixture of 2-bromo-5-iodo-1,3-dimethylbenzene (500 mg), 1,2,4-triazole (340 mg), potassium carbonate (770 mg), and copper(I) iodide (232 mg) in N-methyl-2-pyrrolidinone is stirred at 130° C. over night. More potassium carbonate (770 mg) and copper(I) iodide (232 mg) are added and the mixture is heated to 150° C. for 4 h. After cooling to room temperature the mixture is diluted with tetrahydrofuran and filtered. The filtrate is concentrated in vacuo and purified by HPLC on reversed phase to give the title compound. LC (method 7): tR=0.99 min; Mass spectrum (ESI+): m/z=252, 254 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US08642585B2 |
|---|
| Source dataset | uspto-grants-2014_02 |
|---|
| ORD ID | ord-b98bb9696f9d46da995aab369deb0b92 |
|---|
| Source note | uspto-grants-2014_02 |
|---|
