HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylene → HCID 24786837, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylene | HCID 8255 | — |
| Reactant | Sodium Chlorite | HCID 23668197 | — |
| Reactant | Monosodium phosphate | HCID 23672064 | — |
| Reactant | Benzyl 5-formyl-1H-pyrrole-2-carboxylate | HCID 71349636 | — |
| Solvent | 1-Butanol | HCID 263 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 24786837 | HCID 24786837 | — |
Reaction Steps
To a solution of 5-formyl-1H-pyrrole-2-carboxylic acid benzyl ester (8.0 g) in n-butanol (300 mL) and water (112 mL) was added sodium dihydrogen phosphate (6.28 g), sodium chlorite (9.47 g) and isobutene (58g). The mixture was stirred for 20 h at RT after which it was concentrated. After purification of the residue by flash column chromatography on silica (DCM/MeOH 15:1 to 1:1) 10.0 g of 1H-pyrrole-2,5-dicarboxylic acid monobenzyl ester were obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07465806B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-bf9f22643c92426a96a196d51c048f84 |
| Source note | uspto-grants-2008_12 |