HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 11421420, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 11179038 | HCID 11179038 | — |
| Reactant | 3-Methoxyazetidine | HCID 13401996 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | HCID 11421420 | HCID 11421420 | — |
Reaction Steps
To a solution of 1-[5-(5-chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-4-(1-isopropyl-piperidin-4-ylcarbamoyl)-1H-pyrrole-2-carboxylic acid (example 17, 9 mg) in DCM (2 mL) was added HATU (7.2 mg), DIEA (13 μL) and 3-methoxy-azetidine. The mixture was stirred for 1 h at RT and then concentrated. The residue was purified by preparative HPLC(CH3CN/H2O gradient+0.05% TFA) to give 1-[5-(5-Chloro-thiophen-2-yl)-isoxazol-3-ylmethyl]-5-(3-methoxy-azetidine-1-carbonyl)-1H-pyrrole-2-carboxylic acid (1-isopropyl-piperidin-4-yl)-amide (4.3 mg) as its trifluoroacetate salt. MS (ESI+): m/e=546 [M+H]+, chloro pattern.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07465806B2 |
| Source dataset | uspto-grants-2008_12 |
| ORD ID | ord-eda384904ddb4c5e866586325d01b818 |
| Source note | uspto-grants-2008_12 |