Methanesulfonyl chloride → HCID 11704228, compound

Participants

Reaction Steps

(1H-Indazol-5-yl)-[6-(1,2,3,6-tetrahydro-pyridin-4-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-yl]-amine hydrochloride (80 mg, 0.217 mmol), Hunigs base (113 μL, 0.653 mmol) and methanesulfonyl chloride (17 μL, 0.2177 mmol) were combined in DMF at rt and stirred overnight. The reaction was concentrated in vacuo and residue purified on silica gel by elution with tetrahydrofuran:dichloromethane (3:2) to yield the title compound as white solid. 1H NMR (d6-DMSO, 400 MHz) 9.4(1H, br. s), 8.4 (1H, s), 8.3(1H,s), 8.0(1H,s), 7.7(1H, d), 7.5(1H, d), 6.8(1H, s), 6.4(1H,s), 3.9(2H, s), 3.4(2H, m), 3.0(3H,s) and 2.6(2H, s); LC/MS: m/z 410 [M+H]+, Rt=2.82 min.

Provenance & Evidence