1-Methylpiperazine → Phenylmethyl α,α,4-trimethyl-1-piperazinepropanoate

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The procedure for benzyl-2,2-dimethyl-3-piperidin-1-ylpropanoate was followed except for replacing piperidine with 1-methylpiperazine. Purification via silica gel chromatography (5% EtOAc in hexane) afforded the title compound as a yellow oil. MS (ES+): m/z: 291.20 (100) [MH+]. HPLC: tr=2.08 min (ZQ2000: polar—5 min). 1H NMR (400 MHz, CDCl3): δ=1.18 (s, 6H), 2.09 (s, 3H), 2.23-2.33 (m, 4H), 2.39-2.50 (m, 6H), 5.11 (s, 2H) 7.31-7.36 (m, 5H)

Provenance & Evidence