反应详情

A suspension of 4-[4-(3-chloro-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (45.4 mg, 0.0945 mmol, 1 eq) in 4.0 M of HCl in 1,4-dioxane (3.25 mL, 140 eq) was allowed to stir at rt for 2 h. The reaction was concentrated in vacuo to dryness, affording the title compound, as a yellow solid. 1H NMR (400 MHz, MeOH-d4): δ=2.83 (s, br, 2H), 3.52 (t, J=6.0 Hz, 2H), 3.95 (s, br, 2H), 6.44 (s, 1H), 6.83 (s, br, 1H), 7.56 (d, J=8.8 Hz, 1H), 7.75 (dd, J=8.8, 0.8 Hz, 1H), 8.19 (s, 1H), 8.28 (d, J=0.8 Hz, 1H). MS (ES+): m/z 365.98/368.00 (20/8) [MH+]. HPLC: tR=0.48 & 1.56 min (ZQ2000, polar—5 min).

1. concentrationThe reaction was concentrated in vacuo to dryness