Thiophene-3-boronic acid → HCID 58710044, compound

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The title compound was prepared following the procedure for tert-butyl 4-{4-[3-(1H-pyrrol-2-yl)phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-6-yl}-3,6-dihydro-2H-pyridine-1-carboxylate, but using 3-thienylboronic acid. 1H-NMR (CD3OD, 400 MHz): δ=1.50 (s, 9H), 2.56 (m, 2H), 3.67 (m, 2H), 4.13 (m, 2H), 6.30 (s, br, 1H), 6.66 (s, 1H), 7.37-7.42 (m, 2H), 7.47-7.50 (m, 2H), 7.63-7.66 (m, 2H), 8.01-8.02 (m, 1H), 8.23 (s, 1H). MS (ES+): m/z 474.04 [MH+]. HPLC: tR=3.58 min (ZQ2000, polar—5 min).

Provenance & Evidence