HCID 178526836, compound → HCID 178508039, compound

Participants

Reaction Steps

A solution of 5-nitro-3-thiazol-5-ylpyridin-2-ol (218 mg, 0.977 mmol) and 10% Pd/C (100 mg) in methanol (5 mL) was hydrogenated under 1 atm at rt for 5 h. The resulting mixture was filtered through a Celite pad. The filtrate was concentrated under reduced pressure to give 170 mg of the title compound, which was used directly in the next step without purification. 1H-NMR (DMSO-d6, 400 MHz): δ=4.38 (s, br, 2H), 6.78 (d, J=2.8 Hz, 1H), 7.80 (d, J=2.8 Hz, 1H), 8.41 (s, 1H), 8.97 (s, 1H), 11.52 (s, br, 1H). MS (ES+): m/z 194.15 [MH+]. HPLC: tR=0.49 and 0.90 min (ZQ2000, polar—5 min).

Provenance & Evidence