HCID 58709968, compound → HCID 58709843, compound

Participants

Reaction Steps

Dimethyl-{2-[2-(3-nitrophenyl)imidazol-1-yl]ethyl}amine (88 mg, 0.34 mmol) in methanol (5 mL) was hydrogenated in the presence of 10% Pd/C (80 mg) for 16 h. The reaction mixture was filtered through a Celite pad. The filtrate was concentrated in vacuo to afford the title compound, which was used directly in the next step without purification. 1H-NMR (CDCl3, 400 MHz): δ=2.23 (s, 6H), 2.63 (t, J=7.2 Hz, 2H), 4.13 (d, J=7.2 Hz, 2H), 6.72-6.75 (m, 1H), 6.90-6.92 (m, 1H), 6.96 (t, J=2.0 Hz, 1H), 7.08 (d, J=1.2 Hz, 1H), 7.11 (d, J=1.2 Hz, 1H), 7.22 (t, J=7.6 Hz, 1H). MS (ES+): m/z 231.22 [MH+]. HPLC: tR=0.33 min (ZQ2000, polar—5 min).

Provenance & Evidence