Hydrochloric Acid → HCID 178434295, compound

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Reaction Steps

To a suspension of 4-[4-(3-methyl-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (488 mg, 1.10 mmol) in MeOH (10 mL) was added hydrogen chloride (9M in MeOH, 2.15 mL, 19.4 mmol), the mixture was stirred at rt for 3 h and concentrated in vacuo. The residue was triturated with Et2O and dried in vacuo to give the title compound. MS (ES+): m/z 347.12 (10) [MH+]. HPLC: tR(polar—5 mins)=1.52 min (ZQ2000, polar—5 min). A purified sample was made by Gilson HPLC to record the 1H NMR spectrum. 1H NMR (DMSO-d6, 400 MHz): δ=2.34 (s, 3H), 2.47 (brs, 2H), 3.12 (brs, 2H), 3.60 (brs, 2H), 6.29 (s, 1H), 6.92 (s, 1H), 7.07 (s, 1H), 7.19 (s, 1H), 7.25 (d, 1H, J=8.4 Hz), 7.40 (d, 1H, J=8.4 Hz), 7.75 (s, 1H), 8.06 (s, 1H), 9.27 (brs, 1H), 12.73 (brs 1H).

Provenance & Evidence