Hydrochloric Acid → HCID 69275387, compound

Participants

Reaction Steps

A 4.0 M solution of HCl in 1,4-dioxane (4.7 mL; 20 eq) was added to a suspension of 4-[4-(1-methyl-1H-indazol-5-ylamino)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-3,6-dihydro-2H-pyridine-1-carboxylic acid tert-butyl ester (415.4 mg, 0.9324 mmol, 1 eq) in 1,4-dioxane (8 mL) and stirred at rt for 2 h. The solid was filtered off, washed several times with dioxane, and dried under vacuum, yielding the title compound, as a yellow solid. 1H NMR (400 MHz, DMSO-d6): δ=2.65 (s, br, 2H), 3.32 (s, br, 2H), 3.80 (s, br, 2H), 4.11 (s, 3H), 6.50 (s, 1H), 7.04 (s, br, 1H), 7.51 (dd, J=8.8, 1.6 Hz, 1H), 7.83 (d, J=9.2 Hz, 1H), 7.98 (s, 1H), 8.15 (s, 1H), 8.26 (s, 1H), 9.43 (s, br, —NH+—NH), 11.56 (s, br, —NH), 13.09 (s, H+). MS (ES+): m/z 346.16 (31) [MH+]. HPLC: tR=1.57 min (ZQ2000, polar—5 min).

Provenance & Evidence