5-Chloro-2-methylpyridazin-3(2H)-one → HCID 86697261, compound

HRID 237596Notes

Reaction equation

HRID 237596 reaction equation
Cl[C:2]1[CH:7]=[N:6][N:5]([CH3:8])[C:4](=[O:9])[CH:3]=1.[CH3:10][C:11]1[CH:17]=[C:16](B2OC(C)(C)C(C)(C)O2)[CH:15]=[C:14]([CH3:27])[C:12]=1[NH2:13]>>[NH2:13][C:12]1[C:14]([CH3:27])=[CH:15][C:16]([C:2]2[CH:7]=[N:6][N:5]([CH3:8])[C:4](=[O:9])[CH:3]=2)=[CH:17][C:11]=1[CH3:10]

Participants

3

Reactant 2

HCID 129101445-Chloro-2-methylpyridazin-3(2H)-oneHCID 567377242,6-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline

Product 1

HCID 86697261HCID 86697261, compound

Conditions

Temperature
60 °C

Procedure

The title compound is prepared from 5-chloro-2-methylpyridazin-3(2H)-one and 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline following a procedure analogous to that described in Step 2 of Intermediate 62. The mixture is stirred for 12 hours at 60° C. LC (method 9): tR=0.79 min; Mass spectrum (ESI+): m/z=230 [M+H]+.

Sources & evidence

ORD record
ord-89b36b271300475e9281ae71b306bb86
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

Loading…