4-Chloro-2-methoxypyrimidine → 4-(2-Methoxypyrimidin-4-yl)-2,6-dimethylaniline

Participants

Role	Name	HCID	Charge
Reactant	4-Chloro-2-methoxypyrimidine	HCID 575230	—
Reactant	2,6-Dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline	HCID 56737724	—
Product	4-(2-Methoxypyrimidin-4-yl)-2,6-dimethylaniline	HCID 86697264	—

Reaction Conditions

Temperature	60 °C

Reaction Steps

The title compound is prepared from 4-chloro-2-methoxypyrimidine and 2,6-dimethyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)aniline following a procedure analogous to that described in Step 2 of Intermediate 62. The mixture is stirred for 12 hours at 60° C. LC (method 14): tR=0.89 min; Mass spectrum (ESI+): m/z=230 [M+H]+.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08642585B2
Source dataset	uspto-grants-2014_02
ORD ID	ord-af1cfec148d342fd8921d7d62c16b150
Source note	uspto-grants-2014_02