1-Chloroethyl chloroformate → HCID 86603628, compound

Participants

Reaction Steps

1-Chloroethyl chloroformate (1.88 mL) was added a mixture of ethyl (2E)-3-(2-[(1-benzyl-4-piperidyl)amino]-1,3-thiazol-4-yl)acrylate (2.7 g) in dichloromethane (40 mL) at ambient temperature and the mixture was stirred at same temperature for 1.5 hour. The solvent was removed by concentration. To the residue was added an EtOH (42.7 mL) and the mixture was stirred at 70° C. for 2 hours. The reaction mixture was added 2N-ethanolic hydrogen chloride (7.3 mL) at ambient temperature and the mixture was stirred at same temperature for 20 hours. The isolated precipitate was collected by filtration to give ethyl (2E)-3-[2-(4-piperidylamino)-1,3-thiazol-4-yl]acrylate dihydrochloride (1.44 g).

Provenance & Evidence