HuagongsheHuagongshe Chemistry Print Report · For research reference only
{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester → HCID 178500720, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | {(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 86697103 | — |
| Reactant | {(S)-6-[(R)-7-fluoro-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl ester | HCID 86697106 | — |
| Reactant | 5-(4-Bromo-3,5-dimethylphenyl)-2H-1,2,3,4-tetrazole | HCID 86697267 | — |
| Product | HCID 178500720 | HCID 178500720 | — |
Reaction Steps
The title compound is prepared from 5-(4-bromo-3,5-dimethylphenyl)-1H-tetrazole and methyl 2-((S)-6-((R)-7-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,3-dihydro-1H-inden-1-yloxy)-2,3-dihydrobenzofuran-3-yl)acetate following a procedure analogous to that described in Step 5 of Intermediate 1. LC (method 11): tR=1.05 min; Mass spectrum (ESI+): m/z=515 [M+H]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08642585B2 |
| Source dataset | uspto-grants-2014_02 |
| ORD ID | ord-8c9a31a97b3e448ba1997748e6cca55f |
| Source note | uspto-grants-2014_02 |