HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2376068Generated: October 30, 2026
Ethyl Acetate → ethyl (2E)-3-(2-{[(3R)-1-(cyclohexylmethyl)-3-pyrrolidinyl]amino}thiazol-4-yl)acrylate hydrochloride
https://huagongshe.com/reaction/2376068
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | ethyl (2E)-5-chloro-4-oxo-2-pentenoate | HCID 86603623 | — |
| Reactant | 1-[(3R)-1-(cyclohexylmethyl)-3-pyrrolidinyl]thiourea | HCID 86603691 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | ethyl (2E)-3-(2-{[(3R)-1-(cyclohexylmethyl)-3-pyrrolidinyl]amino}thiazol-4-yl)acrylate hydrochloride | HCID 86603689 | 60.9% |
Reaction Steps
The mixture of ethyl (2E)-5-chloro-4-oxo-2-pentenoate (0.8 g) and 1-[(3R)-1-(cyclohexylmethyl)-3-pyrrolidinyl]thiourea (1.09 g) in CH3CN (16 mL) was stirred at 70° C. for 2 hrs. To the reaction mixture was added an AcOEt (32 mL) and isolated precipitate was collected by filtration to give ethyl (2E)-3-(2-{[(3R)-1-(cyclohexylmethyl)-3-pyrrolidinyl]amino}thiazol-4-yl)acrylate hydrochloride (1.10 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07465731B2 |
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| Source dataset | uspto-grants-2008_12 |
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| ORD ID | ord-d96fea0cd894429bb65165735116a37b |
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| Source note | uspto-grants-2008_12 |
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