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HRID2376070

反应详情

EQUATION

反应方程式

HRID 2376070 的结构方程式

REACTANTS

反应物

1
结构：CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ncc(CO)cc2Cl)C1
HCID86603693

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCC[C@@H](Nc2ncc(C=O)cc2Cl)C1
HCID86603692

未命名化合物

收率 91.3%

AUXILIARIES

试剂、催化剂与溶剂

2
结构：[O]=[Mn]=[O]
催化剂HCID14801

Manganese oxide (Mn2O4)

MnO2

结构：ClC(Cl)Cl
溶剂HCID6212

Chloroform

CHCl3

CONDITIONS

反应条件

温度
60 °C

PROCEDURE

实验过程

A mixture of tert-butyl (3R)-3-{[3-chloro-5-(hydroxymethyl)-2-pyridinyl]amino}-1-piperidinecarboxylate (10.0 g) and MnO2 (25.4 g) in CHCl3 (200 ml) was stirred at 60° C. for 3.5 hours. After removal of the insoluble material, and the solvent was evaporated in vacuo to give tert-butyl (3R)-3-[(3-chloro-5-formyl-2-pyridinyl)amino]-1-piperidinecarboxylate (9.08 g).

WORKUP

后处理

  1. customAfter removal of the insoluble material
  2. customthe solvent was evaporated in vacuo