反应详情

To a solution of ethyl (2E)-3-(6-{(tert-butoxycarbonyl)[(3R)-1-(4-nitrophenyl)-3-pyrrolidinyl]amino}-3-pyridinyl)acrylate (297 mg) in ethanol (3 mL) was added tin(II) chloride (583 mg), and the mixture was heated at reflux for 6 hours. After cooling, the reaction mixture was basified with 2N sodium hydroxide and extracted with ethyl acetate. The organic layer was dried over Na2SO4, filtered, and evaporated in vacuo. The residue was purified by column chromatography on silica gel to give ethyl (2E)-3-(6-{[(3R)-1-(4-aminophenyl)-3-pyrrolidinyl]amino}-3-pyridinyl)acrylate (186 mg).

1. temperaturethe mixture was heated
2. temperatureat reflux for 6 hours
3. temperatureAfter cooling
4. extractionextracted with ethyl acetate
5. dry with materialThe organic layer was dried over Na2SO4
6. filtrationfiltered
7. customevaporated in vacuo
8. customThe residue was purified by column chromatography on silica gel