(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate → HCID 89808964, compound

HRID 237612Notes

Reaction equation

HRID 237612 reaction equation
[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[C:13]([O:18][CH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[N:14][CH:15]=[CH:16][CH:17]=2)=[C:6]2[C:10]=1[C@@H:9]([OH:11])[CH2:8][CH2:7]2.O[C:25]1[CH:38]=[CH:37][C:28]2[C@H:29]([CH2:32][C:33]([O:35][CH3:36])=[O:34])[CH2:30][O:31][C:27]=2[CH:26]=1.BrC1C=CC(F)=C2C=1CC[C@H]2OC1C=CC2[C@H](CC(OC)=O)COC=2C=1>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:12]2[C:13]([O:18][CH2:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[N:14][CH:15]=[CH:16][CH:17]=2)=[C:6]2[C:10]=1[C@H:9]([O:11][C:25]1[CH:38]=[CH:37][C:28]3[C@H:29]([CH2:32][C:33]([O:35][CH3:36])=[O:34])[CH2:30][O:31][C:27]=3[CH:26]=1)[CH2:8][CH2:7]2

Participants

4

Reactant 3

HCID 53393313(S)-Methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetateHCID 86697103{(S)-6-[(R)-4-bromo-7-fluoro-indan-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-acetic acid methyl esterHCID 89808905HCID 89808905, compound

Product 1

HCID 89808964HCID 89808964, compound

Procedure

The title compound is prepared from (1S)-7-fluoro-4-(2-(neopentyloxy)pyridin-3-yl)-2,3-dihydro-1H-inden-1-ol and (S)-methyl 2-(6-hydroxy-2,3-dihydrobenzofuran-3-yl)acetate following a procedure analogous to that described in Step 3 of Intermediate 1. LC (method 15): tR=1.32 min.

Sources & evidence

ORD record
ord-87cf695d1a284a8ab1ed6013f108fbfa
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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