Sodium Bicarbonate → HCID 136335097, compound

Participants

Reaction Steps

To a solution of (2E)-3-(5-{[(3R)-1-benzyl-3-pyrrolidinyl]amino}-2-pyrazinyl)-N-hydroxyacrylamide dihydrochloride (1.00 g) in water (10 mL) was added saturated NaHCO3 at 4° C. (to pH 7-8). The mixture was extracted with CHCl3 three times. The conbined organic layer was dried over Na2SO4, filtered, and evaporated in vacuo to give (2E)-3-(5-{[(3R)-1-benzyl-3-pyrrolidinyl]amino}-2-pyrazinyl)-N-hydroxyacrylamide (796 mg).

Provenance & Evidence