Ethanol hydrochloride → HCID 86603828, compound

Participants

Reaction Conditions

Reaction Steps

A solution of 2N HCl-EtOH solution (1.2 ml) was added to a mixture of (2E)-3-{2-[(1-benzyl-3-pyrrolidinyl)amino]-4-methyl-5-pyrimidinyl}-N-(tetrahydro-2H-pyran-2-yloxy)acrylamide (200 mg) in EtOH (5 ml) and stirred at 20-25° C. for 2 hours. IPE (30 ml) was added to a reaction mixture and the resultant mixture was stirred at ambient temperature for 20 minutes. The precipitate was collected by filtration to give (2E)-3-(2-[(1-benzyl-3-pyrrolidinyl)amino]-4-methyl-5-pyrimidinyl)-N-hydroxyacrylamide dihydrochloride (90 mg).

Provenance & Evidence