Ethyl Acetate → HCID 69198828, compound

Participants

Reaction Steps

To a flask containing ethyl acetate (1.0 mL), ethanol (1.0 mL) and a catalytic amount of Raney nickel was added 5-[5-(3,4-dichloro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrazol-3-yl]-4-m-tolyl-pent-2-enoic acid methyl ester (92 mg, 0.17 mmol). The reaction mixture was stirred under H2 (˜1 atm) for 2 h and then filtered through a CELITE® pad. The filtrate was concentrated under reduced pressure, and the crude residue was purified by reversed-phase HPLC giving the desired ester (81 mg, 91%). HPLC: Rt=3.68 (Method B). MS (ESI): mass calculated for C29H28Cl2N3O3, 522.15; m/z found, 523.3 [M+H]+.

Provenance & Evidence