1-Isopropyl-4-(2-methyl-3-(4-methylphenoxy)propene-1-yl)benzene → 2-(1-(4-Isopropylphenyl)-2-methyl-2-propenyl)-4-methylphenol

Participants

Reaction Conditions

Reaction Steps

A solution of 1-isopropyl-4-(2-methyl-3-(4-methylphenoxy)propene-1-yl)benzene obtained in Reference Example 87 (8.2 g, 29.2 mmol) in N,N-dimethylaniline (50 mL) was stirred under argon atmosphere at 215° C. for 16 hours. After cooling, the reaction mixture was diluted with diisopropyl ether, washed with 5 N hydrochloric acid and water, dried over magnesium sulfate, and then concentrated under reduced pressure. The obtained residue was purified by silica gel column chromatography (hexane:ethyl acetate=4:1) to obtain 7.80 g (yield 95%) of the title compound. Oily matter.

Provenance & Evidence