MeOH tetrahydrofuran → HCID 23113862, compound

HRID 2376338Notes

Reaction equation

[Br:1][C:2]1[C:12](C)=[CH:11]C(OCC(C)=O)=[C:4]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=2)[C:3]=1[CH3:24].[CH3:25]O.[CH2:27]1[CH2:31][O:30][CH2:29][CH2:28]1>>[Br:1][C:2]1[C:3]([CH3:24])=[C:4]([CH2:14][C:15]2[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=2)[C:31]2[O:30][CH:29]=[C:28]([CH3:25])[C:27]=2[C:12]=1[CH3:11]

Participants

Reactant 2

HCID 21899815MeOH tetrahydrofuran

HCID 23114331HCID 23114331, compound

Product 1

HCID 23113862HCID 23113862, compoundYield 84%

Procedure

Using 1-(4-bromo-1-(2-(4-isopropylbenzyl)-3,5-dimethylphenoxy)acetone obtained in Reference Example 189, the title compound was synthesized in the same manner as in Reference Example 143. Yield 84%. Melting point: 76-77° C. (methanol-THF).

Workup

customobtained in Reference Example 189

Sources & evidence

ORD record: ord-ec82db65cdd04d4d865a6d9756abca62
Source dataset: uspto-grants-2008_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07465815B2

Reaction notes

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