反应详情

温度

80 °C

A mixture of 1-(4-methylphenyl)-2-(2,3,5-trimethylphenoxy)ethanone obtained in Reference Example 163 (1.0 g, 3.73 mmol) and polyphosphoric acid (6.0 g) was stirred at 80° C. for one and half hours. Water was added to the reaction solution, which was extracted with ethyl acetate. The organic layer was washed with a saturated sodium hydrogen carbonate solution, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure to obtain 770 mg (yield 83%) of the title compound. Melting point: 112-113° C. (ethyl acetate-methanol).

1. extractionwas extracted with ethyl acetate
2. washThe organic layer was washed with a saturated sodium hydrogen carbonate solution
3. dry with materialdried over anhydrous sodium sulfate
4. concentrationconcentrated under reduced pressure