Ethyl acetate hexane → HCID 68705577, compound

HRID 2376438Notes

Reaction equation

HRID 2376438 reaction equation
Br[C:2]1[C:10]2[O:9][CH2:8][C@H:7]([C:11]3[CH:16]=[CH:15][C:14]([CH:17]([CH3:19])[CH3:18])=[CH:13][CH:12]=3)[C:6]=2[C:5]([CH3:20])=[C:4]([NH:21][C:22](=[O:28])[CH2:23][C:24]([CH3:27])([CH3:26])[CH3:25])[C:3]=1[CH3:29].[C:30](OCC)(=[O:32])C.CCCCCC>C(Cl)(Cl)Cl>[CH:17]([C:14]1[CH:13]=[CH:12][C:11]([C@@H:7]2[C:6]3[C:5]([CH3:20])=[C:4]([NH:21][C:22](=[O:28])[CH2:23][C:24]([CH3:26])([CH3:25])[CH3:27])[C:3]([CH3:29])=[C:2]([O:32][CH3:30])[C:10]=3[O:9][CH2:8]2)=[CH:16][CH:15]=1)([CH3:18])[CH3:19]

Participants

4

Reactant 2

HCID 21226206Ethyl acetate hexaneHCID 68707779HCID 68707779, compound

Product 1

HCID 68705577HCID 68705577, compoundYield 98%

Reagents, catalysts & solvents 1

HCID 6212ChloroformSolvent

Procedure

Using (−)-N-((3R)-7-bromo-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)-3,3-dimethylbutanamide obtained in Example 51, the title compound was synthesized in the same manner as in Example 36. Yield: 98%. Melting point: 150-151° C. (ethyl acetate -hexane). [α]D20=+55.9° (c=0.50, chloroform).

Sources & evidence

ORD record
ord-f92a5fc9eb184a67a6c9cf9208fdf967
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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