Chloroform → HCID 68707165, compound

HRID 2376441Notes

Reaction equation

HRID 2376441 reaction equation
[CH:1]([C:4]1[CH:9]=[CH:8][C:7]([C@H:10]2[C:14]3[C:15]([CH3:21])=[C:16]([NH2:20])[C:17]([CH3:19])=[CH:18][C:13]=3[O:12][CH2:11]2)=[CH:6][CH:5]=1)([CH3:3])[CH3:2].CCC[CH2:25][CH2:26][CH3:27].C([O:31][CH2:32][CH3:33])(=O)C.[CH:34](Cl)(Cl)Cl>>[CH:1]([C:4]1[CH:5]=[CH:6][C:7]([C@H:10]2[C:14]3[C:15]([CH3:21])=[C:16]([NH:20][C:32](=[O:31])[CH2:33][C:26]([CH3:25])([CH3:27])[CH3:34])[C:17]([CH3:19])=[CH:18][C:13]=3[O:12][CH2:11]2)=[CH:8][CH:9]=1)([CH3:3])[CH3:2]

Participants

4

Reactant 3

HCID 6212ChloroformHCID 21226206Ethyl acetate hexaneHCID 68705588HCID 68705588, compound

Product 1

HCID 68707165HCID 68707165, compoundYield 84%

Procedure

Using (S)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-amine obtained in Reference Example 326, the title compound was synthesized in the same manner as in Example 1. Yield: 84%. Melting point: 147-148° C. (hexane-ethyl acetate). [α]D20=−93° (c=0.497, chloroform).

Workup

  1. customobtained in Reference Example 326

Sources & evidence

ORD record
ord-2817826ea27045deb4fb9e62d789ebe9
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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