Ethanolamine → HCID 23114031, compound

HRID 2376498Notes

Reaction equation

HRID 2376498 reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:29])[NH:6][C:7]1[C:8]([CH3:28])=[C:9]([CH2:26][CH3:27])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25].[NH2:32][CH2:33][CH2:34][OH:35]>CCCCCC.C(OCC)(=O)C>[CH2:26]([C:9]1[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:17][CH:16]=3)[C:11]=2[C:24]([CH3:25])=[C:7]([NH:6][C:5]([NH:32][CH2:33][CH2:34][OH:35])=[O:29])[C:8]=1[CH3:28])[CH3:27]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86618059HCID 86618059, compound

Product 1

HCID 23114031HCID 23114031, compoundYield 57%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl(7-ethyl-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 139 and 2-aminoethanol, the title compound was synthesized in the same manner as in Example 143. Yield: 57%. Melting point: 147-148° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-db7931a70ee043a1b70f3edb24db376a
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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