Ethanolamine → HCID 23114002, compound

HRID 2376499Notes

Reaction equation

HRID 2376499 reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:29])[NH:6][C:7]1[C:8]([CH3:28])=[C:9]([O:26][CH3:27])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25].[NH2:32][CH2:33][CH2:34][OH:35]>CCCCCC.C(OCC)(=O)C>[OH:35][CH2:34][CH2:33][NH:32][C:5]([NH:6][C:7]1[C:8]([CH3:28])=[C:9]([O:26][CH3:27])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:16]=[CH:17][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:19][CH:20]=3)[C:11]=2[C:24]=1[CH3:25])=[O:29]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86618060HCID 86618060, compound

Product 1

HCID 23114002HCID 23114002, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl(3-(4-isopropylphenyl)-7-methoxy-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 140 and 2-aminoethanol, the title compound was synthesized in the same manner as in Example 143. Yield: 59%. Melting point: 127-129° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-6f7912b0169e4d2baab1f3b0a8e23651
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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