2-Bromo-5-cyclopropylpyrazine → HCID 86697323, compound

HRID 237650Notes

Reaction equation

HRID 237650 reaction equation
[Cl:1][C:2]1[C:7]([CH3:8])=[CH:6][C:5](B2OC(C)(C)C(C)(C)O2)=[CH:4][C:3]=1[CH3:18].Br[C:20]1[CH:25]=[N:24][C:23]([CH:26]2[CH2:28][CH2:27]2)=[CH:22][N:21]=1>>[Cl:1][C:2]1[C:3]([CH3:18])=[CH:4][C:5]([C:20]2[CH:25]=[N:24][C:23]([CH:26]3[CH2:28][CH2:27]3)=[CH:22][N:21]=2)=[CH:6][C:7]=1[CH3:8]

Participants

3

Reactant 2

HCID 457876352-Bromo-5-cyclopropylpyrazineHCID 532171282-(4-Chloro-3,5-dimethylphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Product 1

HCID 86697323HCID 86697323, compound

Procedure

The title compound is prepared from 2-chloro-1,3-dimethyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzene and 2-bromo-5-cyclopropyl-pyrazine following a procedure analogous to that described in Step 1 of Intermediate 56. LC (method 11): tR=1.28 min; Mass spectrum (ESI+): m/z=259/261 (Cl) [M+H]+.

Sources & evidence

ORD record
ord-f7a2984409b64615a905b91e0f0d2acc
Source dataset
uspto-grants-2014_02
Patent number
US08642585B2

Reaction notes

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