Ethanolamine → HCID 23114430, compound

HRID 2376500Notes

Reaction equation

HRID 2376500 reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:31])[NH:6][C:7]1[C:8]([CH3:30])=[C:9]([CH2:26][CH2:27][CH2:28][OH:29])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25].[NH2:34][CH2:35][CH2:36][OH:37]>CCCCCC.C(OCC)(=O)C>[OH:37][CH2:36][CH2:35][NH:34][C:5]([NH:6][C:7]1[C:8]([CH3:30])=[C:9]([CH2:26][CH2:27][CH2:28][OH:29])[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25])=[O:31]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86618061HCID 86618061, compound

Product 1

HCID 23114430HCID 23114430, compoundYield 53%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl(7-(3-hydroxypropyl)-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 141 and 2-aminoethanol, the title compound was synthesized in the same manner as in Example 143. Yield: 53%. Melting point: 153-154° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-19758723b6454b31b1e75df0744e81d9
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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