Ethanolamine → HCID 23113907, compound

HRID 2376502Notes

Reaction equation

HRID 2376502 reaction equation
ClC(Cl)(Cl)CO[C:5](=[O:33])[NH:6][C:7]1[C:8]([CH3:32])=[C:9]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:23])[CH3:22])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25].[NH2:36][CH2:37][CH2:38][OH:39]>CCCCCC.C(OCC)(=O)C>[OH:39][CH2:38][CH2:37][NH:36][C:5]([NH:6][C:7]1[C:8]([CH3:32])=[C:9]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=2)[C:10]2[O:14][CH2:13][CH:12]([C:15]3[CH:20]=[CH:19][C:18]([CH:21]([CH3:22])[CH3:23])=[CH:17][CH:16]=3)[C:11]=2[C:24]=1[CH3:25])=[O:33]

Participants

4

Reactant 2

HCID 700EthanolamineHCID 86618062HCID 86618062, compound

Product 1

HCID 23113907HCID 23113907, compoundYield 59%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using 2,2,2-trichloroethyl(3-(4-isopropylphenyl)-4,6-dimethyl-7-phenyl-2,3-dihydro-1-benzofuran-5-yl)carbamate obtained in Example 142 and 2-aminoethanol, the title compound was synthesized in the same manner as in Example 143. Yield: 59%. Melting point: 152-155° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-315056b5d7da49159964bd85faa6e179
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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