HCID 23113986, compound → HCID 23114280, compound

HRID 2376510Notes

Reaction equation

HRID 2376510 reaction equation
[CH:1]([C:3]1[C:11]2[S:10][CH2:9][CH:8]([C:12]3[CH:17]=[CH:16][C:15]([CH:18]([CH3:20])[CH3:19])=[CH:14][CH:13]=3)[C:7]=2[C:6]([CH3:21])=[C:5]([NH:22][C:23](=[O:29])[CH2:24][C:25]([CH3:28])([CH3:27])[CH3:26])[C:4]=1[CH3:30])=O.[CH2:31]([Mg]Br)[CH3:32]>CCCCCC.C(OCC)(=O)C>[CH:18]([C:15]1[CH:16]=[CH:17][C:12]([CH:8]2[C:7]3[C:6]([CH3:21])=[C:5]([NH:22][C:23](=[O:29])[CH2:24][C:25]([CH3:26])([CH3:28])[CH3:27])[C:4]([CH3:30])=[C:3]([CH2:1][CH2:31][CH3:32])[C:11]=3[S:10][CH2:9]2)=[CH:13][CH:14]=1)([CH3:20])[CH3:19]

Participants

4

Reactant 2

HCID 23113986HCID 23113986, compoundHCID 178418443HCID 178418443, compound

Product 1

HCID 23114280HCID 23114280, compoundYield 22%

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Using N-(7-formyl-3-(4-isopropylphenyl)-4,6-dimethyl-2,3-dihydro-1-benzothien-5-yl)-3,3-dimethylbutanamide obtained in Example 163 and ethylmagnesium bromide, the title compound was synthesized in the same manner as in Example 164. Yield: 22%. Melting point: 159-160° C. (hexane-ethyl acetate).

Sources & evidence

ORD record
ord-095c5f8aacb7420eac5a3eeaae480b6c
Source dataset
uspto-grants-2008_12
Patent number
US07465815B2

Reaction notes

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